slime fish could be the key to the development of new antibiotics, researchers say.
Antibiotic resistance to & # 39 is a growing threat, with warnings by experts about the return to a situation where everyday infections can become life-threatening. NHS strives to reduce the use of antibiotics by 15% until 2024 in an attempt to solve this problem – which has been named a danger to humanity – while the government also announced that it is considering incentives for pharmaceutical companies to come up with new antibiotics.
But scientists are also on the case. Now researchers say that new antibiotics can be found in the mucus layer that covers the outer surface of the fry.
While she mucus helps protect fish from the harmful bacteria, fungi and viruses, the team is interested in the collection of microorganisms with it & # 39 is home to – the so-called microbiome – and substances which it produces.
"We believe that the bacteria in the mucus add chemistry antiseptic forces mucus and that new biologically active compounds can be found in fish microbiome," said Dr. Sandra Loesgen, head of the research group at the University of Oregon.
The study, presented at the spring national meeting of the American Chemical Society in Orlando, Florida, the team involved swabbing 17 species of fish caught in the southern California coast.
A total of 47 different bacterial strains were grown separately detected and cocktails substances in mucus of fish produced were collected and tested for their antimicrobial skill.
Team speak a number of strains derived chemical compounds that have been able to address methicillin-resistant aurococcusOr of MRSA, with a smaller share, capable of solving E wand. Some of them have also proved effective against the problem of yeast Candida Albicansand even colon cancer cells.
While the team says it is not clear from the & # 39 are bacteria found part of the typical surface flora species of fish, they are currently working to dissolve what is material within chemical compounds for anti-microbial effect.
"So far we have analyzed in detail only one strain [found on a pink surfperch] and no new chemicals have not been found, "said Loesgen. But, she added, there is still much to strains.
Dr. Webber, an expert on antibiotic resistance at Quadram Institute of Biological, said that while the study was in its early stages, it was important to hunt antibiotics in unusual places.
"Most of our current antibiotics were originally identified by the microbes that live in soil and produce them to kill other competing bacteria. Now we are faced with an acute shortage of new antibiotics for use in humans, so the search for new drugs in other environments with the & # 39 is an exciting and timely, "he said. "New drugs are found bacteria living on fish are active only against some of our major pathogens of concern, but it may be possible to change them or to find a future drugs effective against the most dangerous superbugs."
Laura Piddock, professor of microbiology at the University of Birmingham, was also cautiously optimistic.
"Stay antimicrobial substances to any of the natural environment with the & # 39 is useful in the search for new antibiotics – especially if they are active against pathogens WHO's priority," she said. "However, going from tubes to a safe and effective drug in the patient's only the beginning of a long and expensive process of drug development."