Monday , April 12 2021

Finding ways to measure tumor aggression

Selangor, Malaysia, November 27, 2018 – (ACN Newswire) – Researchers at the University Putra Malaysia have found a link between certain markers of inflammation in the body and the aggressiveness of certain cancers.

They spent a full body scan 31 people with cancer – including lung cancer, esophagus, colon and breast cancer – with the help of a machine that combines PET and computed tomography (PET / CT). Scans were evaluated malignancy and tumor aggressiveness on the basis of measurements, called maximum standardized uptake (SUVmax). The more particular radiopharmaceutical tracer closed cell, the darker he & # 39 is in the figures and the above scan SUVmax. Traditionally, a tumor with a value SUVmax 2,5 g / ml or higher are considered malignant. The group was divided into two parts on the basis of tumor SUVmax values ​​higher or lower than 6.0.

Team Body mass index as measured by the patient (BMI), a measure of obesity; Fasting blood sugar levels; and the level of blood markers of inflammation, including C-reactive protein, a substance produced by the liver in response to inflammation, and interleukin 6, an immune protein that is active during inflammation.

They found a strong correlation between SUVmax and C-reactive protein. They also found a strong correlation between the levels of C-reactive protein and interleukin-6 levels. Finally, there were strong correlations between interleukin 6 levels, BMI and fasting glucose in the blood.

They found that the level of fasting blood glucose and interleukin-6 levels, in particular, were good predictors of tumor aggression. blood glucose level and a post increased interleukin gradually decreased, the higher the value SUVmax tumor was above 6.0. This may mean that the increase in the level of blood sugar in people with tumors that have SUVmax values ​​above 6.0 indicates that they are becoming increasingly aggressive. Falling levels of interleukin-6 in high tumors SUVmax, on the other hand, may indicate effective treatment.

"The serum inflammatory markers and endogenous glucose is associated with a potentially more aggressive malignant cancer," the researchers conclude in their study, published in the journal Pertanika Science & Technology. "In particular, Interleukin 6 may be used as a useful surrogate marker of the tumor aggressiveness with important prognostic value," they write.

Further studies, however, it is necessary to understand why Interleukin 6 level is changed in this way.

Reference document: Saad Ahmad, F. et al, "Association of FDG-PET (Suvmax) and inflammatory Marker in tumor aggressiveness prediction» Pertanika Science & Technology journal. 2018

Distributed to Pertanika magazine Science & Technology of ResearchSEA.

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