Sunshine West woman has died on board the flight from Los Angeles to Melbourne.
Police are awaiting the results of pathological after the death of 34-year-old, who was on board the 16-hour flight QF 94.
Cabin crew assisted two doctors in the air and were met with medical personnel when the plane landed just before 9 am today.
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"We are very grateful for their help," said a spokesman for Qantas.
"Medical Services met the aircraft on arrival in Melbourne."
The exact cause of death of women yet to be determined.
The woman who was on the flight to social media to express their outrage at the death.
"Someone actually died on my flight back home," she wrote on Snapchat.