Thursday , December 3 2020

Chronic fatigue syndrome may be caused by an overactive immune system, says study



(CNN) – According to one study, chronic fatigue syndrome, a condition that causes extreme fatigue, can be caused by an overactive immune system.

British researchers have found that exaggerated immune response can cause long-lasting fatigue, believing that this is how the condition begins, also known as myalgic encephalomyelitis, or MS.

In a study published on Monday, with the & # 39 is the first to shed light on the role of the immune system in the development of the disease, multisystem disorder that very little is known, according to lead researcher Carmine Pariante, Professor of Biological Psychiatry, King's College London.

Limited information to date has made treatment of the problem.

Pariante explained that in many cases of chronic fatigue patients recall an infection like a cold or other viral infection in the early stages of disease development.

"We've had this information for quite some time, but we did not know what was going on in the body of these patients," he said.

According to the British charity event to me, about 250 000 people in the UK and 17 million people worldwide suffer from chronic fatigue. An estimated 836,000 to 2.5 million Americans are struggling syndrome, according to the Centers for Control and Prevention of diseases (CDC, for its acronym in English).

In order, as it is known that the treatment causes constant fatigue in some people to try to get more information, the team modeled the possible path to a condition based on the treatment of chronic hepatitis C infections, called interferon alpha.

The study explains that alpha interferon affects the immune system in a similar way to a strong infection.

Researchers measured fatigue and immune activity in 55 patients treated for hepatitis C with interferon alpha.

Patients were monitored before, during and after treatment for hepatitis C. Participants 18 patients, about one-third developed prolonged fatigue, defined as fatigue for more than six months after treatment.

The Group also felt fatigue lasting greater immune response, as indicated by a doubling of the levels of messenger molecules of the immune system of interleukin-10 and interleukin-6.

Immunological markers were measured with blood during the study.

The Group also noted higher levels of these molecules in these patients to treatment began.

"What these data suggest strongly that people who develop chronic fatigue syndrome in response to infection, they do so because their immune system is overactive ready to react," explained Pariante.

It is not clear why the human immune system can be ready to respond to hyperactive, but genetics may be a possible cause, he added.


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