Ronald Reagan died at the age of 93, do not remember who was the president of the United States during the Cold War. Rita Hayworth died at 68 years old, not knowing that they were carried out GildaAnd Adolfo Suárez ended 81 forgetting that it was the first Democratic president in Spain after Franco's death. Every three seconds a new case of dementia is diagnosed worldwide, with devastating results. More than a century after the discovery of Alzheimer's disease, there is still no cure or even well understood his reasons.
An international team of scientists has published a document which may help to explain why the experimental treatments are not able to, one after another for several years. The so-called Alzheimer's disease Alzheimer's disease is not always. Researchers led by American Peter Nelson, describe a new type of dementia, called late that appears as often as Alzheimer's disease in people over 80 years. It went unnoticed for decades. "There are more than 200 different viruses that can cause colds. Why do we believe that there is only one cause of dementia? "There is Nelson, University of Kentucky, said in a statement.
"Many clinical trials of Alzheimer's disease treatment, not because they are including patients who are to be excluded," warns Maria Angeles Martin Requero
Traditionally, scientists have identified two proteins by binding to Alzheimer's disease beta-amyloid, which accumulates between brain cells, and tau, which also reaches harmful levels and forms tangles in the brain. In the new type of dementia, all, researchers pay attention to another protein, TDP-43, and is also involved in other diseases of the nervous system such as amyotrophic lateral sclerosis.
"Until now, the most common dementia with & # 39 is Alzheimer's disease, which has a peak incidence between 65 and 80 years," explains biochemist Jesús Ávila, scientific director of the Center for Research Foundation of neurological diseases (CIEN), in Madrid. "Now this work specified, and by mutual agreement, the presence of other diseases for the elderly. There are, in accordance with the increase in the average life, new types of dementia & # 39 are, "adds Avila.
The study's authors argue that there are signs of MBE to more than 20% of the analyzed brain of people older than 80 years. "Many clinical treatment trials for Alzheimer's disease fail because they & # 39 are including patients who are to be excluded," warns Maria Angeles Martin Requero, whose lab at the Center for Biological Research (CSIC) in Madrid, explores the role TDP -43 protein in dementia. "Late likely to respond to different types of treatment of Alzheimer's disease," agrees psychologist Nina Silverberg, the US National Institute on Aging.
Director of the Brain Bank CIEN Foundation calls for increased contributions
Team neurological Virginia Lee of the University of Pennsylvania, observed in 2006, the presence of clusters in the protein TDP-43 in the fronto-share degeneration of the brain, one of the main types of dementia, with Alzheimer's disease, Lewy body dementia and vascular dementia. To late, TDP-43 are often concentrated in the amygdala and hippocampus, two brain regions associated, respectively, with emotion and autobiographical memory.
Albert Radish spent years watching these accumulations of TDP-43 in neurons. He directs the Bank CIEN Foundation of the brain, 155 organs donated by patients Foundation Alzheimer Center of the Queen Sofia, Madrid's Vallecas district. "We have always said that Alzheimer's disease, after 85 years, it seems, another disease. In such extreme ages, dementia with & # 39 is the sum of pathologies. We Alzheimer's disease, Alzheimer's disease Parkinson's disease, cerebral vascular disease, TDP-43 inclusions … ", said the expert.
The authors of the new study, published in the journal brain, Note that more and more people over 80 years all over the world and, therefore, "Late have growing influence and little-known in the field of public health." There is "an urgent need for research," they warn. Radish, meanwhile, do not appeal to the people, "to donate their brains."
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