Chinese studies have identified neuronal group linked scratch in mice, which could help in the development of new drugs for chronic itching. Itching can be caused by many reasons, including allergies, irritation of chemicals, parasites, pregnancy and heat treatmentNTS cancer.
Pruritus is essential for the survival of animals. Animals can get rid of harmful substances in the skin, such as itching, leading to a & # 39; scratching. In some cases, damage to the skin caused by the bristles can cause a strong immune response.
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But patients with chronic itching can damage the skin by scratching compulsively. Effective treatment is still lacking due to limited impact on the neural mechanisms behind itching knowledge.
Previous studies have shown that the periaqueductal gray (PAG), a deep brain region serves as the main control center for the modulation of pain. Researchers from the Institute of Neuroscience, Chinese Academy of Sciences suspect that the PAG may also be involved in the process of itching.
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In a study published in the latest issue of the American Journal of the Neuron, Chinese researchers recorded the activity of neurons in the PAG myshe between laboratory-induced itch and scratches.
If mice induced with zero, AML neurons called neurotransmitters glutamate manufactured and neuropeptide called TAC1.
The researchers found that scratching behavior induced itching is significantly reduced if the PAG neurons producing TAC1 were eliminated. In contrast, TAC1 stimulation producing neurons caused spontaneous scratching even when the mouse is not induced to sting.
Sun Yangang, lead author of the study, said that he and his team plan to investigate which molecules produce neurons PAG TAC1 can be targeted in future studies of medicines.
"These studies will help us to develop new approaches and the development of new drugs for the treatment of patients with chronic itch," Sun said