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Study finds older people continue to generate new neurons



Mexico A new study published in Nature Medicine, notes that even people older than middle-aged (43-87 years) can produce new brain cells, and that previous studies have failed to detect these newcomers could use faulty methods.

According to the NAU Global, the work "provides accurate and reliable, that neurogenesis persists throughout the life of the evidence," says Paul Frankland, a neurologist at the Hospital for Sick Children in Toronto, Canada.

Llorens Maria Martin, co-author of the study and researcher at the Center of Molecular Biology Severo Ochoa (CBM) shows that the area of ​​the brain called the dentate gyrus, produces new neurons into the ninth decade of life.

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Incidentally Llorens explains that the birth of new neurons in the adult brain is of great importance for modern medicine, because it is a special type generated by neurons in the hippocampus is involved in the acquisition of new memories and learning in mice. "Our study provides the data is still unknown how mature these cells in the human dentate gyrus," he added, a Spanish explorer.

"These results are of great importance in neurodegenerative diseases. Early detection of reducing the generation of new neurons may be an early marker for Alzheimer's disease, "he said.

Some scientists remain skeptical, including the authors of nature in the past year. "Although this study provides valuable data, we have not found any conclusive evidence of continuing production of new neurons in the adult human hippocampus," says Shawn Sorrells, a neuroscientist at the University of Pittsburgh in Pennsylvania, article co-author, in which it was reported that neurogenesis disappears in adolescence.

Much of the discussion depends on the methods used to test, for example, DCX staining that Sorrells says it's not a & # 39 is an adequate measure of young neurons because DCX protein is also expressed on mature cells. This indicates that the "new" team found that the neurons were actually present since childhood, he says. The new study also found no evidence of groups of stem cells, which can give new neurons, he says.

Llorens Martin says his team used several other proteins associated with the development of neurons, to confirm that DCX-positive cells were very young, and they were "very strict" in their criteria for identifying young neurons.

(With information science and nature)

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