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Excess body weight at the age of 50 is associated with a high risk of pancreatic cancer mortality



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While pancreatic cancer with the & # 39 is relatively rare, accounting for just over 3% of all new cancer cases, it is a very dangerous form of cancer. In the US, cancer of the pancreas with a & # 39 is the third leading cause of cancer death, after lung and colorectal cancer, and is expected to cause about 46,000 deaths in 2019.

"Pancreatic cancer incidence has been steadily increasing since the beginning of the 2000s," says lead author, Eric J. Jacobs (American Cancer Society, Georgia, United States). "We were puzzled by the fact that the increase is because smoking a major risk factor pancreatic cancer is reduced. "

"Weight gain in the US population with a & # 39 is a likely suspect, but previous studies have shown that being overweight is associated with only a relatively small increase in risk, that does not look big enough to fully explain the recent increase in the incidence of pancreatic cancer," Jacobs continued .

In this study, the researchers wanted to find out when the excess weight is measured in early adulthood may be more closely associated with the risk of developing pancreatic cancer than overweight measured in adulthood.

The researchers examined data from the 963.317 US adults without a history of cancer, which is registered in a national study of cancer mortality, which began in 1982 and the subsequent party until 2014; American Cancer Society Prevention Study II cancer. At baseline, all participants reported their weight and height. This included several participants at the age of 30 years while the others were in their 70s or 80s. Body mass index (BMI) is then calculated based on this information.

During the observation period, 8.354 participants died from pancreatic cancer. As expected, higher body mass index was associated with an increased risk of death from pancreatic cancer, but this increased risk was greatest for BMI measured at an earlier age. Jacobs said that while the study was only about death from pancreatic cancer, the disease is almost always fatal, so the results are expected to be similar to those for new diagnoses of pancreatic cancer.

The findings suggest that being overweight can increase the risk of death from pancreatic cancer more than previously thought. In addition, the researchers wrote that the latest generation of reach early middle age with more overweight than the previous generations used to do. This indicates that being overweight will explain most of the pancreatic risk in the future.

Interestingly, according to Jacobs estimates that 28% of pancreatic cancer deaths among Americans born between 1970 and 1974 is associated with being overweight, compared to only 15% of Americans, born in 1930, which significantly less likely to suffer from obesity in early middle age, therefore, it emphasizes the importance of preventing overweight before middle age to reduce the rate of pancreatic cancer.

"Our results strongly suggest that in order to halt and eventually reverse the recent increase in pancreatic cancer, we need to do better in the prevention of obesity in children and young adults, the achievement of which would have helped to avoid many other diseases, and also, "he concluded Jacobs,

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