call ERC Advanced Grant 2018 for established researchers received over 2,050 applications, of which were selected for funding 11 percent, which reflects the considerable success of the Slovenian researcher at the press conference, said director Institute of Chemistry Gregor Anderluh.
Ole will be using the ERC at NIC has established a new research group in which the word Anderluh takes approximately six to eight researchers Department of Molecular Biology and Nanobiotechnology, Part of the project will be implemented University College London (Saa).
The five-year project called RNP Dynamics investigate how the regulation of RNA molecules contribute to the development and functioning of the brain and as defects in the regulation lead to neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), with the help of video conferencing told Slovenian researcher and a professor of molecular neuroscience at UCL-ROM Ole.
In addition, the project has studied how errors in contacts between proteins and RNA-jem (ribonucleic acid) disrupt neurons and thus cause ALS disease. This will be the basis for the development of new strategies for the treatment of diseases with RNA molecules.
According Anderluh with & # 39; is a major research project in which they will not develop the drug for the ALS, the better they will understand the causes of this disease. "I am confident that the results of the project will be from & # 39; be the basis for drug development and strategies for the treatment of this disease in the future" said Anderluh.
The study will be based on techniques that accompany the entire cellular network of contacts between molecules, which will create a large amount of data. These data will then be the basis for computer & # 39; computer analysis that will look for changes in interact with molecules with & # 39 are key to the dynamics of molecular complexes and thereby cause the early development of the brain.
Researchers at the Institute of Chemistry will participate in the project, especially in the field of structural chemistry and structural chemistry, and thus to contribute to the understanding of the structure and interaction of molecules in the field of computer & # 39; computer modeling of processes occurring in the molecules in our body.
Several projects instititutu in Chemistry
Uli project & # 39 is the eighth project by ERC, which is carried out in a research organization in Slovenia and the fifth project in the scheme established by the researchers. This is the second project in Slovenia ERC Institute of Chemistry, the first entitled macchines, Acquired last year Roman Geral.
Anderluh the event the project on schedule was presented Marie Curie Skodlowska – Individual scholarships to researchers from India and Italy, and research equipment that will soon be installed in their laboratories.
According to him, the institute this year also plans to upgrade research equipment National Center for NMR spectroscopy HD and the acquisition of new krioelektronskega microscope that is unique in the region. This survey of buildings and complexes of biological macromolecules at atomic resolution, so, "Will greatly facilitate research opportunities, particularly in the life sciences"Says Anderluh.
During the presentation of the microscope will be prepared in the Institute of Chemistry Symposium, which will be held Nobel laureate joachim FrankIt was in 2017, together with researchers Jacques Dubochetom and Richard Henderson Nobel Prize in Chemistry for developing krioelektronske microscopy.
As the cells in the brain that regulate gene expression
Slovenian Jernej Ule researcher finished Biotechnical Faculty in Ljubljana and then a doctorate at Rockefeller University in New York in 2004. In 2006, he created a research group in England, first at Cambridge and currently with the & # 39; is a professor molecular neurobiology at UCL in London and leads the research team, Francis Crick Institute.
It deals with the question of how to create a contact between the proteins and the RNA molecule, and it plays an important role in gene expression. During his doctoral thesis, he developed a new method for this purpose, he said, the CLIP, his group was then further developed options such as iCLIP and hiCLIP. With these methods, the study of how brain cell regulates the expression of genes.