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Study: Not only antibiotics – even one in four drug destroys our gut flora


discovering new adverse side effects in every four medicines

Antibiotics are known to the killer bacteria that are fighting both beneficial and harmful bacteria. A recent study showed that at present, in addition, more than one in four drugs affects the nature in the human gut bacteria. This previously unknown side effects can be long-term negative health effects, as well as contribute to the development of antibiotic resistance, not taking antibiotics.

European research group "European Molecular Biology Laboratory" discovered a previously unknown side effects in 1000 more than a quarter of the investigated drugs. According to the survey, about one in four drugs have adverse effects on up to 40 different species of bacteria that our gut flora (microbes) are crucial value. The exact consequences of this influence is not yet in sight. The researchers keep a long-term negative effect on health, most likely. The results of the study were presented recently at the prestigious h asopise «Nature».

High current study found a previously unknown side effect of approximately every fourth drug. Apparently, a lot more drugs affect our intestinal flora than previously thought. The health consequences are currently unknown. (Photo: Andreas Shindl /

Intestinal flora is becoming increasingly important in health research

In studies of the last decade he has shown time and again the importance of the composition of the intestinal microbiome for overall health. If the antibiotic drugs has long been known that they can cause great damage to the intestinal flora. The fact that this also occurs in many nya-antibiotic has been to such an extent, but it is still unknown.

This is just the tip of the iceberg

This paper describes Nature first time as around one in four drugs, sun antibiotic which inhibits growth of various intestinal bacteria. This unknown side effect was found in drugs from all therapeutic classes. "How many different types of drugs to pull intestinal microbes affected, it was really weird," she says Peer Bork leader of the group in a press release on the results of the study. Bork holds this discovery is just the tip of the iceberg. These studies indicate that the actual number of products even more with this side effect.

Side-effects unknown sequence

"We still do not know how many of these drugs act on the microbes that experience these effects in humans, in the days and how this affects, for example, on the health of patients," adds colleague Kiran Patil. These relations should be immediately investigated in order to improve the understanding and effectiveness of existing drugs.

Antibiotic resistance without antibiotics

The annex to the potential health risks that affect the intestinal microbe could also contribute to the development of antibiotic resistance, are not you taking antibiotics. The researchers explain that this is due to the general resistance mechanisms operating against both antibiotics and other drugs. "It's really scary if you think that the people throughout his life, often away, to take medication for a long time," explained Nassos Typas of the research team.

In the area of ​​intestinal bacteria do not understand a lot

"Fortunately, not all entirely antibiotics affect intestinal bacteria, not all resistance will continue to spread," said Typas. Interestingly, even can increase the effectiveness of some antibiotics, resistance to certain non-antibiotics. This, in turn, opens up new possibilities for the optimal combination of drugs.

Everyone has a different intestinal flora

"All people are different in their composition microbiome, which could explain why different patients differently to the same drugs react," reports Georg Zeller of the research team. Attached to some types of bacteria that we all have in common, some people have very different strains of bacteria within their microbiome, the expert believes. This indicates personalized, taking into account the individual patient's intestinal microbiome treatment. For more information on the intestinal flora in the article: to build the intestinal flora: How it works!

The intestine has a great influence on our health

The exact effects of intestinal microbes are still being studied in many studies. It is becoming increasingly clear that the microbiome in the gut, has a big impact on our overall health. For example, this is the secret of a healthy heart in the intestinal flora. Recently we discovered another research group at the University of Colorado Boulder. Researchers have shown that changes in Darmmikrobioms with age can affect heart health. (Vb),

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