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A new mechanism responsible for migraine – digital magazine Our country


Barcelona, ​​30 Mar (EUROPA PRESS) .- researchers found a mutation in a gene involved in the regulation of neuronal excitability and causes dysfunction of proteins that increase the activity of neurons and cause pain migraine.

In a study published in the journal Neuron and is coordinated by the Sandoz Guillaume researchers, at the University of Nice and the National Center for Scientific Research (CNRS) was attended by scientists from the Institute of Neurosciences from the University of Barcelona (UBNeuro) and Neurophysiology Research Group IDIBAPS participated in the study finds.

The new work opens up new possibilities for the development of future therapeutic strategies against migraine, and not from the & # 39 is very important for the detailed mechanisms involved in migraine attacks with aura, is unknown so far in advance.

The study focused specifically on the ion channels and TRESK Trek, which are located in sensory neurons and slow excessive neuronal activation.

According to the data, the mutation in the gene encoding the ion channel TRESK results in a dysfunctional protein which changes the channel capacity, to reduce the electrical activity.

In parallel with this, the mutation generates other modified protein, which affects the physiological function of other ion channels as TREK1.

The discovery of the mechanism by which mutation produces two proteins dysfunctional process, possibly in conjunction with other pathologies genéticas- also opens new perspectives to be explored in the future.

"Paradoxically, it is still not the other mutations have been described, which also eliminate TRESK protein, but not to provoke a migraine. In the new study, we found that the combination of these two factors, which have a higher electrical activation of sensory neurons, which leads to the characteristic pain of migraine is needed, "he told the researcher Xavier Gasull.

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