The study of more than 300,000 people in Denmark, presented at the European Congress on Obesity in this year in Glasgow (Scotland), shows that the heavier and higher children are more at risk than the average size of renal cell carcinoma (an RCC, its reduction in English) in adulthood.
RCC with & # 39 is the most common form of kidney cancer in adults. It occurs most often in men between the ages of 50 to 70 years, the cancer can be diagnosed in adulthood. Medical experts do not know the exact causes of RCC.
"We know that being overweight in adulthood is associated with increased risk of RCC. We also know that the river will take many years to develop. Thus, we have a theory that overweight children increase the risk of RCC later life, "said lead author, Wang Britt Jensen, Center for Clinical Research and Bispebjerg prevention and Frederiksberg Hospital in Copenhagen, Denmark.
To determine the relationship between childhood body size and risk of RCC in adults, Jensen and his colleagues used data from the data on the health status of the logging Copenhagen School (CSHRR, for its acronym in English). CSHRR is an electronic database of health screening information data with 372.636 children born in Copenhagen in the years 1930-1989 (and from 30 to 89 years today). It contains a consistent height and weight measurements and body weight at birth in 1942 to parents.
In their study, the researchers included 301.422 people (152.573 people) with CSHRR, born from 1930 to 1985. The weight and height of annual medical examinations of school children aged 7-13 years were measured, and used body mass index (BMI) to classify children as normal weight or overweight, according to the specific values of the cut-off age and sex proposed by the International working group on obesity. RCC cases were identified through communication with the Danish Cancer Registry.
For data analysis, researchers used a statistical method known as Cox regression. The procedure applies to a number of factors or events, which are considered at the same time, to measure risk as a result, in this case, the risk of developing CRC.
significant association between BMI and increase the risk of developing cancer
With a median 32 years of follow up, 1,010 people (680 people) were diagnosed with RCC. Men and women, and a significant positive association between BMI and the child's height, respectively, and observed risk of RCC. When comparing two children under the age of 13 years with a difference in BMI z score (equivalent to 5.9 kg to 6.8 kg for boys and girls), but with the same height, the boy or girl was harder in each case 14 per cent higher the risk of RCC is thinner than a child.
For the height difference Z score of two children under the age of 13 years (the equivalent of 8 cm to 6.9 cm for children and girls) was associated with a 12 percent increased risk of RCC later in life the highest child or baby.
Compared with children of normal weight at 7 and 13 years of age, children who are overweight have a 67 percent in both age had a higher risk of PKRA, while children with normal weight at age 7 and overweight at the age of 13 increased the risk of developing this form of cancer.
As compared with children with an average height of 7 and 13 years, children who received a higher score Z 0.5 mean age 7 (equivalent to 2.6 cm for children) and continue even higher than an average of 13 years, 6 percent increased the risk of RCC.
Children grew at an average height to a height above the middle (change of 0.5 points z represents an additional growth height of 4 cm for children and 3.5 cm for females) was 8 percent increased risk of RCC.
The authors say. "We have found in other studies that children's growth is positively related to various forms of cancer this way, we hope that the high children have an increased risk of children the average size of RCC Our conclusion that children. harder and higher have a higher risk of RCC open the door to new ways to explore the causes of kidney cancer. " (I)